AustralieFrV1, Main, Exploration, bibRecord, 004028

Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial

Identifieur interne : 004028 ( Main/Exploration ); précédent : 004027; suivant : 004029

Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial

Auteurs : William Greenhalf [Royaume-Uni] ; Paula Ghaneh [Royaume-Uni] ; John P. Neoptolemos [Royaume-Uni] ; Daniel H. Palmer [Royaume-Uni] ; Trevor F. Cox [Royaume-Uni] ; Richard F. Lamb ; Elizabeth Garner [Royaume-Uni] ; Fiona Campbell [Royaume-Uni] ; John R. Mackey [Canada] ; Eithne Costello [Royaume-Uni] ; Malcolm J. Moore [Canada] ; Juan W. Valle [Royaume-Uni] ; Alexander C. Mcdonald [Royaume-Uni] ; Ross Carter [Royaume-Uni] ; Niall C. Tebbutt [Australie] ; David Goldstein [Australie] ; Jennifer Shannon [Australie] ; Christos Dervenis [Grèce] ; Bengt Glimelius [Suède] ; Mark Deakin [Royaume-Uni] ; Richard M. Charnley [Royaume-Uni] ; François Lacaine [France] ; Andrew G. Scarfe [Canada] ; Mark R. Middleton [Royaume-Uni] ; Alan Anthoney [Royaume-Uni] ; Christopher M. Halloran [Royaume-Uni] ; Julia Mayerle [Allemagne] ; Attila Olah [Hongrie] ; Richard Jackson [Royaume-Uni] ; Charlotte L. Rawcliffe [Royaume-Uni] ; Aldo Scarpa [Italie] ; Claudio Bassi [Italie] ; Markus W. Büchler [Allemagne]

Source :

Journal of the National Cancer Institute [ 0027-8874 ] ; 2014.

RBID : Pascal:14-0055958

Descripteurs français

Pascal (Inist)
- Cancer du pancréas, Survie, Homme, Gemcitabine, Essai clinique, Cancérologie, Anticancéreux.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antineoplastic agent, Cancerology, Clinical trial, Gemcitabine, Human, Pancreas cancer, Survival.

Abstract

Background Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection. Methods Microarrays from 434 patients randomized to chemotherapy in the ESPAC-3 trial (plus controls from ESPAC-1/3) were stained with the 10D7G2 anti-hENT1 antibody. Patients were classified as having high hENT1 expression if the mean H score for their cores was above the overall median H score (48). High and low hENT1-expressing groups were compared using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models. All statistical tests were two-sided. Results Three hundred eighty patients (87.6%) and 1808 cores were suitable and included in the final analysis. Median overall survival for gemcitabine-treated patients (n = 176) was 23.4 (95% confidence interval [CI] = 18.3 to 26.0) months vs 23.5 (95% CI = 19.8 to 27.3) months for 176 patients treated with 5-fluorouracil/folinic acid (χ²₁=0.24; P = .62). Median survival for patients treated with gemcitabine was 17.1 (95% CI = 14.3 to 23.8) months for those with low hENT1 expression vs 26.2 (95% CI = 21.2 to 31.4) months for those with high hENT1 expression (χ²₁= 9.87; P= .002). For the 5-fluorouracil group, median survival was 25.6 (95% CI = 20.1 to 27.9) and 21.9 (95% CI = 16.0 to 28.3) months for those with low and high hENT1 expression, respectively (χ²₁ = 0.83; P = .36). hENT1 levels were not predictive of survival for the 28 patients of the observation group (χ²₁ = 0.37; P = .54). Multivariable analysis confirmed hENT1 expression as a predictive marker in gemcitabine-treated (Wald χ² = 9.16; P = .003) but not 5-fluorouracil-treated (Wald χ² = 1.22; P= .27) patients. Conclusions Subject to prospective validation, gemcitabine should not be used for patients with low tumor hENT1 expression.

Affiliations:

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<author><name sortKey="Rawcliffe, Charlotte L" sort="Rawcliffe, Charlotte L" uniqKey="Rawcliffe C" first="Charlotte L." last="Rawcliffe">Charlotte L. Rawcliffe</name>
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<s3>ITA</s3>
<sZ>31 aut.</sZ>
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</inist:fA14>
<country>Italie</country>
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<s3>ITA</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona</wicri:noRegion>
</affiliation>
</author>
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<s3>DEU</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial</title>
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</affiliation>
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<author><name sortKey="Ghaneh, Paula" sort="Ghaneh, Paula" uniqKey="Ghaneh P" first="Paula" last="Ghaneh">Paula Ghaneh</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
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</affiliation>
</author>
<author><name sortKey="Neoptolemos, John P" sort="Neoptolemos, John P" uniqKey="Neoptolemos J" first="John P." last="Neoptolemos">John P. Neoptolemos</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
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<sZ>1 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Palmer, Daniel H" sort="Palmer, Daniel H" uniqKey="Palmer D" first="Daniel H." last="Palmer">Daniel H. Palmer</name>
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<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Cox, Trevor F" sort="Cox, Trevor F" uniqKey="Cox T" first="Trevor F." last="Cox">Trevor F. Cox</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
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<s3>GBR</s3>
<sZ>1 aut.</sZ>
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<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Lamb, Richard F" sort="Lamb, Richard F" uniqKey="Lamb R" first="Richard F." last="Lamb">Richard F. Lamb</name>
</author>
<author><name sortKey="Garner, Elizabeth" sort="Garner, Elizabeth" uniqKey="Garner E" first="Elizabeth" last="Garner">Elizabeth Garner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
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<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Campbell, Fiona" sort="Campbell, Fiona" uniqKey="Campbell F" first="Fiona" last="Campbell">Fiona Campbell</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
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<s3>GBR</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R." last="Mackey">John R. Mackey</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Cross Cancer Institute and University of Alberta</s1>
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<s3>CAN</s3>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Canada</country>
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</affiliation>
</author>
<author><name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>26 aut.</sZ>
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</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moore, Malcolm J" sort="Moore, Malcolm J" uniqKey="Moore M" first="Malcolm J." last="Moore">Malcolm J. Moore</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Princess Margaret Hospital</s1>
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<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
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</affiliation>
</author>
<author><name sortKey="Valle, Juan W" sort="Valle, Juan W" uniqKey="Valle J" first="Juan W." last="Valle">Juan W. Valle</name>
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<s3>GBR</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
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</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Mcdonald, Alexander C" sort="Mcdonald, Alexander C" uniqKey="Mcdonald A" first="Alexander C." last="Mcdonald">Alexander C. Mcdonald</name>
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<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Beatson West of Scotland Cancer Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carter, Ross" sort="Carter, Ross" uniqKey="Carter R" first="Ross" last="Carter">Ross Carter</name>
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<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Glasgow Royal Infirmary</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C." last="Tebbutt">Niall C. Tebbutt</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Austin Health</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Goldstein, David" sort="Goldstein, David" uniqKey="Goldstein D" first="David" last="Goldstein">David Goldstein</name>
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<s2>New South Wales</s2>
<s3>AUS</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Prince of Wales Hospital and Clinical School University of New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shannon, Jennifer" sort="Shannon, Jennifer" uniqKey="Shannon J" first="Jennifer" last="Shannon">Jennifer Shannon</name>
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<s3>AUS</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Dervenis, Christos" sort="Dervenis, Christos" uniqKey="Dervenis C" first="Christos" last="Dervenis">Christos Dervenis</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Agia Olga Hospital</s1>
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<s3>GRC</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name>
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<s3>SWE</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
<orgName type="university">Université d'Uppsala</orgName>
</affiliation>
</author>
<author><name sortKey="Deakin, Mark" sort="Deakin, Mark" uniqKey="Deakin M" first="Mark" last="Deakin">Mark Deakin</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>University Hospital</s1>
<s2>North Staffordshire</s2>
<s3>GBR</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>University Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Charnley, Richard M" sort="Charnley, Richard M" uniqKey="Charnley R" first="Richard M." last="Charnley">Richard M. Charnley</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Freeman Hospital</s1>
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<s3>GBR</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Freeman Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacaine, Francois" sort="Lacaine, Francois" uniqKey="Lacaine F" first="François" last="Lacaine">François Lacaine</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Hôpital Tenon, Université, Pierre et Marie Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Service de Chirurgie Digestive et Viscérale, Hôpital Tenon</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Scarfe, Andrew G" sort="Scarfe, Andrew G" uniqKey="Scarfe A" first="Andrew G." last="Scarfe">Andrew G. Scarfe</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Cross Cancer Institute and University of Alberta</s1>
<s2>Alberta</s2>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Canada</country>
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</affiliation>
</author>
<author><name sortKey="Middleton, Mark R" sort="Middleton, Mark R" uniqKey="Middleton M" first="Mark R." last="Middleton">Mark R. Middleton</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Churchill Hospital, Oxford University Hospitals NHS Trust</s1>
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<s3>GBR</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Anthoney, Alan" sort="Anthoney, Alan" uniqKey="Anthoney A" first="Alan" last="Anthoney">Alan Anthoney</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>St James's University Hospital</s1>
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<s3>GBR</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>St James's University Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Halloran, Christopher M" sort="Halloran, Christopher M" uniqKey="Halloran C" first="Christopher M." last="Halloran">Christopher M. Halloran</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mayerle, Julia" sort="Mayerle, Julia" uniqKey="Mayerle J" first="Julia" last="Mayerle">Julia Mayerle</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Medicine A, University Medicine Greifswald</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
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</affiliation>
</author>
<author><name sortKey="Olah, Attila" sort="Olah, Attila" uniqKey="Olah A" first="Attila" last="Olah">Attila Olah</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Petz Aladar Hospital</s1>
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<s3>HUN</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Hongrie</country>
<wicri:noRegion>Petz Aladar Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jackson, Richard" sort="Jackson, Richard" uniqKey="Jackson R" first="Richard" last="Jackson">Richard Jackson</name>
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<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rawcliffe, Charlotte L" sort="Rawcliffe, Charlotte L" uniqKey="Rawcliffe C" first="Charlotte L." last="Rawcliffe">Charlotte L. Rawcliffe</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>10 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona</s1>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bassi, Claudio" sort="Bassi, Claudio" uniqKey="Bassi C" first="Claudio" last="Bassi">Claudio Bassi</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona</s1>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W." last="Büchler">Markus W. Büchler</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Surgery, University of Heidelberg</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of the National Cancer Institute</title>
<title level="j" type="abbreviated">J. Natl. Cancer Inst.</title>
<idno type="ISSN">0027-8874</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the National Cancer Institute</title>
<title level="j" type="abbreviated">J. Natl. Cancer Inst.</title>
<idno type="ISSN">0027-8874</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term>
<term>Cancerology</term>
<term>Clinical trial</term>
<term>Gemcitabine</term>
<term>Human</term>
<term>Pancreas cancer</term>
<term>Survival</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cancer du pancréas</term>
<term>Survie</term>
<term>Homme</term>
<term>Gemcitabine</term>
<term>Essai clinique</term>
<term>Cancérologie</term>
<term>Anticancéreux</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine after resection. Methods Microarrays from 434 patients randomized to chemotherapy in the ESPAC-3 trial (plus controls from ESPAC-1/3) were stained with the 10D7G2 anti-hENT1 antibody. Patients were classified as having high hENT1 expression if the mean H score for their cores was above the overall median H score (48). High and low hENT1-expressing groups were compared using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models. All statistical tests were two-sided. Results Three hundred eighty patients (87.6%) and 1808 cores were suitable and included in the final analysis. Median overall survival for gemcitabine-treated patients (n = 176) was 23.4 (95% confidence interval [CI] = 18.3 to 26.0) months vs 23.5 (95% CI = 19.8 to 27.3) months for 176 patients treated with 5-fluorouracil/folinic acid (χ<sup>2</sup>
<sub>1</sub>
=0.24; P = .62). Median survival for patients treated with gemcitabine was 17.1 (95% CI = 14.3 to 23.8) months for those with low hENT1 expression vs 26.2 (95% CI = 21.2 to 31.4) months for those with high hENT1 expression (χ<sup>2</sup>
<sub>1</sub>
= 9.87; P= .002). For the 5-fluorouracil group, median survival was 25.6 (95% CI = 20.1 to 27.9) and 21.9 (95% CI = 16.0 to 28.3) months for those with low and high hENT1 expression, respectively (χ<sup>2</sup>
<sub>1</sub>
 = 0.83; P = .36). hENT1 levels were not predictive of survival for the 28 patients of the observation group (χ<sup>2</sup>
<sub>1</sub>
 = 0.37; P = .54). Multivariable analysis confirmed hENT1 expression as a predictive marker in gemcitabine-treated (Wald χ<sup>2</sup>
 = 9.16; P = .003) but not 5-fluorouracil-treated (Wald χ<sup>2</sup>
 = 1.22; P= .27) patients. Conclusions Subject to prospective validation, gemcitabine should not be used for patients with low tumor hENT1 expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Grèce</li>
<li>Hongrie</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>Attique (région)</li>
<li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>East Middle Sweden</li>
<li>Grand Manchester</li>
<li>Midlands de l'Ouest</li>
<li>Nouvelle-Galles du Sud</li>
<li>Oxfordshire</li>
<li>Svealand</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Athènes</li>
<li>Birmingham</li>
<li>Heidelberg</li>
<li>Manchester</li>
<li>Melbourne</li>
<li>Oxford</li>
<li>Paris</li>
<li>Sydney</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université d'Uppsala</li>
<li>Université de Manchester</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Lamb, Richard F" sort="Lamb, Richard F" uniqKey="Lamb R" first="Richard F." last="Lamb">Richard F. Lamb</name>
</noCountry>
<country name="Royaume-Uni"><noRegion><name sortKey="Greenhalf, William" sort="Greenhalf, William" uniqKey="Greenhalf W" first="William" last="Greenhalf">William Greenhalf</name>
</noRegion>
<name sortKey="Anthoney, Alan" sort="Anthoney, Alan" uniqKey="Anthoney A" first="Alan" last="Anthoney">Alan Anthoney</name>
<name sortKey="Campbell, Fiona" sort="Campbell, Fiona" uniqKey="Campbell F" first="Fiona" last="Campbell">Fiona Campbell</name>
<name sortKey="Carter, Ross" sort="Carter, Ross" uniqKey="Carter R" first="Ross" last="Carter">Ross Carter</name>
<name sortKey="Charnley, Richard M" sort="Charnley, Richard M" uniqKey="Charnley R" first="Richard M." last="Charnley">Richard M. Charnley</name>
<name sortKey="Costello, Eithne" sort="Costello, Eithne" uniqKey="Costello E" first="Eithne" last="Costello">Eithne Costello</name>
<name sortKey="Cox, Trevor F" sort="Cox, Trevor F" uniqKey="Cox T" first="Trevor F." last="Cox">Trevor F. Cox</name>
<name sortKey="Deakin, Mark" sort="Deakin, Mark" uniqKey="Deakin M" first="Mark" last="Deakin">Mark Deakin</name>
<name sortKey="Garner, Elizabeth" sort="Garner, Elizabeth" uniqKey="Garner E" first="Elizabeth" last="Garner">Elizabeth Garner</name>
<name sortKey="Ghaneh, Paula" sort="Ghaneh, Paula" uniqKey="Ghaneh P" first="Paula" last="Ghaneh">Paula Ghaneh</name>
<name sortKey="Halloran, Christopher M" sort="Halloran, Christopher M" uniqKey="Halloran C" first="Christopher M." last="Halloran">Christopher M. Halloran</name>
<name sortKey="Jackson, Richard" sort="Jackson, Richard" uniqKey="Jackson R" first="Richard" last="Jackson">Richard Jackson</name>
<name sortKey="Mcdonald, Alexander C" sort="Mcdonald, Alexander C" uniqKey="Mcdonald A" first="Alexander C." last="Mcdonald">Alexander C. Mcdonald</name>
<name sortKey="Middleton, Mark R" sort="Middleton, Mark R" uniqKey="Middleton M" first="Mark R." last="Middleton">Mark R. Middleton</name>
<name sortKey="Neoptolemos, John P" sort="Neoptolemos, John P" uniqKey="Neoptolemos J" first="John P." last="Neoptolemos">John P. Neoptolemos</name>
<name sortKey="Palmer, Daniel H" sort="Palmer, Daniel H" uniqKey="Palmer D" first="Daniel H." last="Palmer">Daniel H. Palmer</name>
<name sortKey="Rawcliffe, Charlotte L" sort="Rawcliffe, Charlotte L" uniqKey="Rawcliffe C" first="Charlotte L." last="Rawcliffe">Charlotte L. Rawcliffe</name>
<name sortKey="Valle, Juan W" sort="Valle, Juan W" uniqKey="Valle J" first="Juan W." last="Valle">Juan W. Valle</name>
</country>
<country name="Canada"><noRegion><name sortKey="Mackey, John R" sort="Mackey, John R" uniqKey="Mackey J" first="John R." last="Mackey">John R. Mackey</name>
</noRegion>
<name sortKey="Moore, Malcolm J" sort="Moore, Malcolm J" uniqKey="Moore M" first="Malcolm J." last="Moore">Malcolm J. Moore</name>
<name sortKey="Scarfe, Andrew G" sort="Scarfe, Andrew G" uniqKey="Scarfe A" first="Andrew G." last="Scarfe">Andrew G. Scarfe</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C." last="Tebbutt">Niall C. Tebbutt</name>
</region>
<name sortKey="Goldstein, David" sort="Goldstein, David" uniqKey="Goldstein D" first="David" last="Goldstein">David Goldstein</name>
<name sortKey="Shannon, Jennifer" sort="Shannon, Jennifer" uniqKey="Shannon J" first="Jennifer" last="Shannon">Jennifer Shannon</name>
</country>
<country name="Grèce"><region name="Attique (région)"><name sortKey="Dervenis, Christos" sort="Dervenis, Christos" uniqKey="Dervenis C" first="Christos" last="Dervenis">Christos Dervenis</name>
</region>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Lacaine, Francois" sort="Lacaine, Francois" uniqKey="Lacaine F" first="François" last="Lacaine">François Lacaine</name>
</region>
<name sortKey="Lacaine, Francois" sort="Lacaine, Francois" uniqKey="Lacaine F" first="François" last="Lacaine">François Lacaine</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Mayerle, Julia" sort="Mayerle, Julia" uniqKey="Mayerle J" first="Julia" last="Mayerle">Julia Mayerle</name>
</noRegion>
<name sortKey="Buchler, Markus W" sort="Buchler, Markus W" uniqKey="Buchler M" first="Markus W." last="Büchler">Markus W. Büchler</name>
</country>
<country name="Hongrie"><noRegion><name sortKey="Olah, Attila" sort="Olah, Attila" uniqKey="Olah A" first="Attila" last="Olah">Attila Olah</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Scarpa, Aldo" sort="Scarpa, Aldo" uniqKey="Scarpa A" first="Aldo" last="Scarpa">Aldo Scarpa</name>
</noRegion>
<name sortKey="Bassi, Claudio" sort="Bassi, Claudio" uniqKey="Bassi C" first="Claudio" last="Bassi">Claudio Bassi</name>
</country>
</tree>
</affiliations>
</record>

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Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial

Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial

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